The Indians had a chance to clinch both second place and a .500 record, in addition to finishing the season with a nine-game winning streak against the Minnesota Twins, but two tenth-inning runs spoiled all those potential marks.
Shelley Duncan continued his torrid September, hitting a two-run homer to put the Indians up 4-2 in the third, but Fausto Carmona couldn't hold the lead, He gave up single tallies in the fifth and sixth innings, with both runs coming either directly or indirectly via an extra-base. A Denard Span triple set up the run in the fifth, and a two-out Trevor Plouffe in the sixth tied the game.
The Tribe bullpen threw 2.2 innings of scoreless baseball to get the game into extra innings, but once regulation ended, so did to the scoreless streak. Tony Sipp gave up a home run to Rene Tosoni (.194/.267/.306) to open the inning, and an additional run on a Chris Parmalee RBI single.
The Indians got the tying run to the plate in the bottom of the inning when Travis Hafner hit with Carlos Santana on first base and two outs, but Hafner grounded out to the first baseman to end the game and the home schedule. The Indians finished the season 44-37 at Progressive Field.
Jim Thome pinch-hit in the eighth inning, and in what may have been his last plate appearance in an Indians home uniform, worked a walk. (Edit: In the top of the ninth, he went out onto the field, and for one pitch, played third base. After the pitch, he was replaced and left the field to a standing ovation.)
| Highest WPA | Lowest WPA | ||
| Duncan | .204 | Sipp | -.416 |
| Smith | .131 | Carrera | -.230 |
| Donald | .123 | Marson | -.205 |